New Approach Methodologies

New Approach Methodologies (NAMs) are any technology, methodology, approach, or combination that can provide information on chemical hazard and risk assessment to avoid the use of animal testing. Traditional approaches to understanding toxicity of chemicals or environmental conditions have relied on toxicity studies that use laboratory animals (in vivo). Scientific and technological advances have led to the development of non-animal (in vitro / in chemico) or computer (in silico) methodologies or approaches that can be used, avoiding the use of intact animals. NAMs are advanced through sciences such as OMICS and use of High-throughput Testing Screening (HTS) methods. NAMs also include alternative to animal testing methods as well as cross-species extrapolation methods.


Alternative to Animal Testing

Alternative to animal testing methods support reducing the numbers of animals used in testing, refining procedures to minimize pain, suffering, and distress and replacing the use of animals whenever possible.

Fact Sheets


Journal Articles

High-Throughput Screening

High-throughput screening (HTS) methods make increased and more effective use of in vitro and small-scale in vivo methods to generate ecotoxicity data in a cost-effective way.

Journal Articles

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