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Mixture Toxicity: Linking Approaches from Ecological and Human Toxicology

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* ISBN: 978-1-4398-3008-6 Publication Date: 2010 Pages: 320
Please note, this book can only be ordered through our publisher CRC Press.
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Editors: Cornelis A. M. van Gestel, Martijs Jonker, Jan E. Kammenga, Ryszard Laskowski, Claus Svendsen

In the last decade and a half, great progress has been made in the development of concepts and models for mixture toxicity, both in human and environmental toxicology. However, due to their different protection goals, developments have often progressed in parallel and with little integration. Arguably the first book to clearly link ecotoxicology and classic human toxicology, Mixture Toxicity: Linking Approaches from Ecological and Human Toxicology incorporates extensive reviews of exposure to toxicants, toxicokinetics and toxicodynamics, toxicity of mixtures, and risk assessment. Taking an unusual approach from exposure to risk assessment that explores the perspectives of ecotoxicologists, human health specialists, and risk assessors, this book:

  • Compares and contrasts the current state of the art in each field and identifies where one can learn from the other
  • Includes a broad and detailed review of problems related to realistic exposure to pollutants, with special emphasis on exposure to mixtures of toxicants and their combined effects on organisms
  • Presents state-of-the-art information based on in-depth discussions among specialists representing different disciplines and approaches

Focusing on the work published in the last fifteen years, the coverage progresses from exposure to risk assessment, at each step identifying the special complications typically raised by mixtures. It identifies possible cross links and includes recommendations for mutual developments that can improve the state of knowledge on mixture toxicity and ultimately lead to better and more integrated risk assessment.

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