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Biotransformation in Environmental Risk Assessment (CD-ROM)

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* ISBN: 978-1-880611-80-7 Publication Date: 2004 Pages: CD

Editors: Dick Sijm, Jack de Bruin, Pim de Voogt, Watze de Wolf, editors

From an April 1996 SETAC Europe workshop in the Netherlands comes this evaluation of methods to identify the capacity of organisms to biotransform chemicals and the types of data necessary to make decisions in the environmental risk assessment process. Experts with diverse backgrounds—biochemists, toxicologists, ecotoxicologists, and environmental fate experts—address the role of biotransformation in bioaccumulation and toxicity; distribution of enzyme systems over trophic levels, species, and organs; evaluation of the importance of induction, inhibition, and saturation of enzyme systems; methodologies to determine biotransformation and metabolites (qualitative and quantitative; in vitro, in vivo, in situ); evaluation of the possibility of selecting model species from different taxonomic groups, and incorporation of knowledge on biotransformation in the the risk characterization process.