This IG is to “explore and further develop OMICs technologies as an important feature in decision making processes such as weight-of-evidence-based risk assessment, toxicity testing, criteria development environmental monitoring and future applications”. This aim is unique to the OMICs IG, which fills a need that is not yet addressed for any existing IG at SETAC.
There are, nevertheless, synergies with other IGs, including the Animal Alternative IG, because OMICs technologies will likely facilitate the establishment and validation of AOPs, which may help to reduce and replace animal testing. Furthermore, the combined use of measured OMICs responses in a suite of alternative animals –such as biomedical and ecologically relevant fish and amphibian embryos, invertebrates and cell lines– may also be mechanistically improved by linking OMICs responses/assays with regulatory endpoints (lethality, growth and reproduction) and within a phylogenetic context. Despite these synergies, there are significant differences between the two IG groups. Another related IG is “Ecological Risk Assessment IG”, which can synergize with the OMICS IG because both use ERA as an approach and a tool to improve decision making about the environment. The main difference between these two IGs is that the OMICS IG will include processes and applications outside of ERA, and will also focus on applications in human health, which are directly related to the European REACH and EFSA recommendations. The OMICS IG will also provide approaches for cumulative risk assessments or mixtures assessments and criteria approached.
The OMICS IG will take a practical approach and aims to establish knowledge exchange across synergistic IG groups. We will also broaden discussions with diverse other groups to generate overall scientific guidance and directions for future research on OMICS, which will directly impact chemical safety assessment.