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Global Interest Groups: Endocrine Disrupter Testing and RA
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Lisa A. Baumann
Jeffrey C. Wolf




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 Open until the 26th August!

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Welcome to the SETAC Global Interest Group (IG) on Endocrine Disrupter Testing and Risk Assessment (EDTRA) webpage. Participation in the EDTRA IG is open to all interested parties. To become a member, make sure you are signed in to your SETAC account. Then click "Join Group” near the top of this page.


Mission and Scope

  • Serve as a neutral platform and a focal point within SETAC for collaborative research and discussion on the topic of endocrine disrupter testing and risk assessment
  • Have direct and active links with existing and relevant future SETAC interest groups (including, but not limited to the SETAC North America IG on Human Health Risk Assessment, the SETAC OMICS IG, and the SETAC Pharma IG)
  • Stimulate critical assessment and the development of strategic approaches using the best available science
  • Encourage the worldwide incorporation of the best available science and strategic approaches
  • Advance the overall understanding of the fate, effects and potential risk assessment consequences of known and suspected endocrine disrupters
  • Provide scientific support to ensure effective regulatory decision making
  • The scope of the EDTRA IG includes all fields pertinent to conducting effective testing and risk assessments of known or suspected endocrine disrupters such as transport, fate, exposure, effect and impact analysis. All environmental compartments are considered, as well as human health and ecosystem protection.



  • The SETAC EDTRA IG was established in 2012 to serve as a scientific resource to all stakeholders impacted by the topic of endocrine disruption in the environment. 
  • Since the 1990's, numerous research projects have focused on a wide range of chemicals that are known to interact with the endocrine systems of humans and wildlife.
  • Various natural and synthetic chemicals have been found to interfere with the endocrine systems of animals in laboratory studies, while field evidence indicates that endocrine systems of fish and other taxa can be impacted.
  • An environmental risk assessment approach is needed for endocrine disrupters, allowing optimal integration of exposure and effects information.
  • Our ability to conduct whole organism toxicity tests to understand chemical safety and specifically that of (potentially) endocrine disrupting substances has been outpaced by the synthesis of new chemicals for a wide variety of commercial applications (LaLone et al, 2017 DOI:10.1002/etc.3805).
  • Scientists and risk assessors are turning to mechanistically-based studies to increase the efficiency of evaluation of these substances, making greater use of the available in vitro and in silico methods. In this context the Adverse Outcome Pathway (AOP) framework has gained traction in environmental endocrine regulatory science since it offers an effective and systematic means of capturing available knowledge describing linkages between mechanistic data and the apical toxicity endpoints required for regulatory assessments. 


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