EVOGENERATE is a workgroup focused on: "EVOlutionary and multi-GENERATional Effects of
The EVOGENERATE workgroup is part of the OMICs Interest Group. It was originally conceived in 2012 under the Ecological Risk Assessment Interest Group.
A limitation of some ecotoxicity testing procedures
or risk assessment approaches is that they do not consider effects
beyond single generations of exposed organisms. Yet, under continuous
multi-generational exposure, offspring may show lower or higher sensitivity to chemicals than their parent(s) (e.g. acclimation to metals).
Furthermore, an offspring's sensitivity to chemicals, and that of even later
generations, may be affected by their parents' (or grandparents') prior
exposure, even long after exposure has ceased (=trans-generational and/or
epigenetic effects). Finally, in a population context, (micro)-evolutionary mechanisms
(such as selection, mutation, genetic drift, and gene flow may be induced or
altered by chemicals over long exposure times. This would result in changes in
genetic composition of populations with possible consequences such as genetic
diversity loss, genetic adaptation, and costs of adaptation.
Although research activities in this area are currently increasing at a
rapid pace (in part fueled by the rapid advancement of omics technologies), an
important issue remains that most of this research is and has been mainly descriptive
and not fit for implementation in regulatory chemicals assessment and
management. The major aims of the EVOGENERATE working group are to
(i) assess the regulatory significance of evolutionary and multigenerational
effects, (ii) raise awareness of such effects, and (iii) to develop and
promote use of tools, methods and protocols to assess and predict evolutionary
and multigenerational effects, not only in an academic but also in a regulatory
Current chairs of this working group are Elias Oziolor and Jana Asselman
If you are interested in joining this working group and/or actively want
to contribute to achieving our aims, please let us know.