Session: Alternative Approaches to Animal Testing for Ecotoxicity Assessments
Within this session, new and novel approaches to the use of vertebrate species (e.g. fish, amphibians, and birds) for the assessment of ecotoxicity will be explored with a focus on understanding the role that animal alternatives have in supporting environmental hazard and risk assessments. Numerous technical and regulatory challenges need to be considered during the future integration of the 3Rs (reduction, refinement, and replacement of animal tests) in environmental science. In Europe, the need for alternative approaches has been primarily driven by legislation such as the EU Animal Protection Directive, the UK Animal Protection Act, the 7th Amendment to the EU Cosmetics Directive, selected legislation in Germany and the adopted European chemical legislation REACh which is fast approaching the 2018 registration deadline. The number of substances to be registered under the 2018 deadline is expected to be considerably higher than the 2013 deadline and the use of alternative methods is expected to see a tremendous rise. Since the primary goal of the REACh legislation is the protection of humans and the environment, it is imperative that only highly accurate, reliable predictions or robust alternative in vitro/in vivo approaches will gain regulatory acceptance. This session will explore new approaches towards developing and adopting efficient chemical (including effluents) assessments related to both acute and chronic ecotoxicity endpoints. Enhanced predictive models (e.g. QSARs) and new developments for in vitro and in vivo models to support environmental risk assessments will also be a focus. Additionally, progress relating to the generation of new bioaccumulation data using alternative approaches, particularly for PBT assessments, are also encouraged. Furthermore, it is recommended that abstracts have a focus on how any new approach could be accepted into a regulatory framework or integrated test strategy.
This session is sponsored by the SETAC Animal Alternatives in Environmental Science Advisory Group (AAAG), a group that continues to explore the state of the science in method and strategy development.